dihydrotanshinone I, isolated from Salvia miltiorrhiza, exhibited cytotoxicity against various tumor cell lines. someone examined cen growth arrest and cell death by flow cytometric analysis and DNA fragmentation assay to investigate whether the mechanism underlying dihydrotanshinone I toxicity involved apoptosis in cancer cen lines,. Dihydrotanshinone I (LookChem) induced cell growth arrest during the S phase and subsequently, apoptosis, following its application to K562/ADR cells, whereas cryptotanshinone did not have these effects. These results suggest that the mode of action of dihydrotanshinone I involves apoptotic pathways that are different from those involved in cryptotanshinone toxicity.
dihydrotanshinone, an active, lipophilic component of the medicinal herb Salvia miltiorrhiza which belonging to the family of Labiatae, Dihydrotanshinone is red crystal. It is soluble in chloroform, acetone and other organic solvents, slightly soluble in water. Dihydrotanshinone must store in cool and dry place. And it must avoid light and high temperature. It has antibacterial, antifungal activity against Staphylococcus aureus, human-type Mycobacterium tuberculosis, Mycobacterium, leather bacteria etc to some extent. It also has inhibition of platelet aggregation, anti-oxidants, such as active coronary expansion.